Abstract
A series of 1-alkyl-3-phenylthiourea analogues were prepared and evaluated as HDL- and Apo A-I-elevating and triglyceride-lowering agents. Several derivatives were superior to gemfibrozil. The optimal analogue (HDL376) was shown to raise HDL cholesterol in the rat, hamster, dog, and monkey models.
MeSH terms
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Administration, Oral
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Animals
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Centrifugation, Density Gradient
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Cholesterol, HDL / metabolism
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Chromatography, High Pressure Liquid
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Cricetinae
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Dogs
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Drug Evaluation, Preclinical
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Gemfibrozil / pharmacology*
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Haplorhini
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Lipids / chemistry
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Lipoproteins, HDL / metabolism*
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Male
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Models, Chemical
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Phenylthiourea / administration & dosage
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Phenylthiourea / chemical synthesis*
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Phenylthiourea / pharmacology*
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Rats
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Rats, Sprague-Dawley
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Time Factors
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Triglycerides / metabolism
Substances
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Cholesterol, HDL
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Lipids
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Lipoproteins, HDL
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Triglycerides
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Phenylthiourea
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Gemfibrozil